Recent advances in the molecular design and applications of proteolysis targeting chimera-based multi-specific antiviral modality

Viral infections represent a major threat to human health and the global economy; however, most of currently available antiviral drugs are not fully effective in restricting viral replication selecting for drug-resistant variants. Targeted protein degradation technologies promising strategies avoid or delay emergence drug resistance. Among degradation-based multi-specific approaches, proteolysis targeting chimera (PROTAC) is main strategy applied field. In this review we will introduce elements mechanisms action used by PROTAC technology, as well advantages PROTACs over drugs. We also summarize latest progress application research, discuss existing challenges look into future opportunities discovery.